Differing effects of beta-blockers on long-term clinical outcomes following percutaneous coronary intervention between patients with mid-range and reduced left ventricular ejection fraction

Abstract Background The aim of this study was to determine the difference in effects beta-blockers on long-term clinical outcomes between ischemic heart disease (IHD) patients with mid-range ejection fraction (mrEF) and those reduced (rEF). Methods Data were assessed 3508 consecutive IHD who underwent percutaneous coronary intervention (PCI) 1997 2011. Among them, 316 mrEF (EF = 40–49%) 201 rEF < 40%) identified. They assigned groups according users non-users patients, separately. primary outcome a composite all-cause death non-fatal acute syndrome. Results median follow-up period 5.5 years 4.3 patients. Cumulative event-free survival significantly lower group than without ( p 0.003), whereas no observed 0.137) beta-blockers. In multivariate analysis, use associated reduction (hazard ratio (HR), 0.59; 95% confidence interval (CI), 0.36–0.97; 0.036), association among (HR 0.74; CI 0.49–1.10; 0.137). Conclusions Our observational showed that not mrEF, significant rEF.